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The cascade model of mortality

It is often instructive to look at mortality models where the parameters have an underlying meaning in a process.
Written by: Stephen RichardsTags: Filter information matrix by tag: cascade process, Filter information matrix by tag: Makeham-Beard, Filter information matrix by tag: multi-state model

Assumed or presumed?

Mortality modelling and research is often critically dependent upon assumptions, but certainty over whether those assumptions are well-founded may come only with hindsight.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: models, Filter information matrix by tag: expert

Minding our P's, Q's and R's

I wrote earlier that deviance residuals were better than Pearson residuals when examining a model fit for Poisson counts. It is worth expanding on why this is, since it also neatly illustrates why there are limits to models based on grouped counts.

When fitting a model for Poisson counts, an important step is to check the goodness of fit using the following statistic:

\[\tilde{\chi}^2 = \sum_{i=1}^n r_i^2\]

Written by: Stephen RichardsTags: Filter information matrix by tag: Pearson residuals, Filter information matrix by tag: deviance residuals, Filter information matrix by tag: Poisson distribution, Filter information matrix by tag: quantile-quantile plot

Metastatic immunity

In 2013, cancers represented more than one third of the top-fifteen causes of all-age mortality in the UK, irrespective of gender. Despite intensive efforts, for some cancers survival rates have scarcely improved for decades.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: cancer, Filter information matrix by tag: immunotherapy

Some points for integration

The survivor function from age \(x\) to age \(x+t\), denoted \({}_tp_x\) by actuaries, is a useful tool in mortality work. As mentioned in one of our earliest blogs, a basic feature is that the expected time lived is the area under the survival curve, i.e. the integral of \({}_tp_x\). This is easy to express in visual terms, but it often requires numerical integration if there is no closed-form expression for the integral of the survival curve.

Written by: Stephen RichardsTags: Filter information matrix by tag: life expectancy, Filter information matrix by tag: survival curve, Filter information matrix by tag: numerical integration, Filter information matrix by tag: adaptive quadrature, Filter information matrix by tag: Trapezoidal Rule, Filter information matrix by tag: Simpson's Rule

(Mis-)Estimation of mortality risk

One of the risks faced by annuity providers is mis-estimation, i.e. the risk that they have incorrectly assessed the current rates of mortality.
Written by: Stephen RichardsTags: Filter information matrix by tag: parameter correlations, Filter information matrix by tag: orthogonality, Filter information matrix by tag: mis-estimation risk

Sweet and sour

Public health initiatives, such as those being considered in the UK around sugar, carry risks as well as potential benefits for any government. The first consequence of action is the near-certain accusation of presiding over a nanny state.

Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: sugar tax, Filter information matrix by tag: obesity, Filter information matrix by tag: diabetes, Filter information matrix by tag: health intervention

Working with constraints

Regular readers of this blog will be aware of the importance of stochastic mortality models in insurance work.
Written by: Stephen RichardsTags: Filter information matrix by tag: Lee-Carter, Filter information matrix by tag: identifiability constraints, Filter information matrix by tag: GLM

The age pattern of mortality

Heligman and Pollard published a famous paper in 1980 with the title "The age pattern of mortality". In their paper they proposed an additive, three-component model of mortality:

\[q_x/p_x = f_I(x) + f_S(x) + f_A(x)\]

Written by: Iain CurrieTags: Filter information matrix by tag: Heligman-Pollard model, Filter information matrix by tag: accident hump, Filter information matrix by tag: shape penalty, Filter information matrix by tag: smoothness penalty

Old drugs, new tricks

Breakthrough science in the longevity space doesn't always require the development of new medicines. In fact, there are significant advantages to repurposing medicines already in use, since some of the most expensive aspects of drug development lie in establishing human safety in the trial phase.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: regenerative medicine, Filter information matrix by tag: cognitive impairment, Filter information matrix by tag: diabetes