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A momentary diversion

An important quantity in mathematical statistics is the moment of a distribution, i.e. the expected value of a given power of the observations. Moments can be either raw, centred about a particular value or standardised in some way. The simplest example is the mean of a distribution: this is the raw first moment, i.e. the expected value of each observation raised to the power 1:

Written by: Stephen RichardsTags: Filter information matrix by tag: moments, Filter information matrix by tag: mean, Filter information matrix by tag: standard deviation, Filter information matrix by tag: kurtosis, Filter information matrix by tag: sample size

Cart before horse?

Predicting the exact impact of weight upon mortality has proven to be a tricky business. That obesity is on the rise is universally acknowledged, but in recent years we have seen research studies reach differing conclusions, depending on the populations examined and the measures used.

Written by: Gavin RitchieTags: Filter information matrix by tag: mortality, Filter information matrix by tag: research, Filter information matrix by tag: reverse causality, Filter information matrix by tag: obesity, Filter information matrix by tag: BMI

Definitions of age

When modelling longevity, age is well-known to be a crucial risk factor. However it is also well-known that the life-expectancy upon attaining any specific age will differ between populations.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: genetics, Filter information matrix by tag: centenarians, Filter information matrix by tag: age

Further reducing uncertainty

In a previous posting I looked at how using a well founded statistical model can improve the accuracy of estimated mortality rates. We saw how the relative uncertainty for the estimate of \(\log \mu_{75.5}\) could be reduced from 20.5% to 3.9% by using a simple two-parameter Gompertz model:

\(\log \mu_x = \alpha + \beta x\qquad (1)\)

Written by: Stephen RichardsTags: Filter information matrix by tag: estimation error, Filter information matrix by tag: mis-estimation risk, Filter information matrix by tag: survival models

Label without a cause

To talk informally about a concept, we need only give it a recognisable name. For example, we use the label "medical error" and we all know what is meant - or at least we think we do.
Written by: Gavin RitchieTags: Filter information matrix by tag: cause of death, Filter information matrix by tag: ICD, Filter information matrix by tag: medical error, Filter information matrix by tag: research

Parameterising the CMI projection spreadsheet

The CMI is the part of the UK actuarial profession which collates mortality data from UK life offices and pension consultants. Amongst its many outputs is an Excel spreadsheet used for setting deterministic mortality forecasts. This spreadsheet is in widespread use throughout the UK at the time of writing, not least for the published reserves for most insurers and pension schemes.

Written by: Stephen RichardsTags: Filter information matrix by tag: CMI, Filter information matrix by tag: expert judgement, Filter information matrix by tag: Lee-Carter, Filter information matrix by tag: drift model

The cascade model of mortality

It is often instructive to look at mortality models where the parameters have an underlying meaning in a process.
Written by: Stephen RichardsTags: Filter information matrix by tag: cascade process, Filter information matrix by tag: Makeham-Beard, Filter information matrix by tag: multi-state model

Assumed or presumed?

Mortality modelling and research is often critically dependent upon assumptions, but certainty over whether those assumptions are well-founded may come only with hindsight.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: models, Filter information matrix by tag: expert

Minding our P's, Q's and R's

I wrote earlier that deviance residuals were better than Pearson residuals when examining a model fit for Poisson counts. It is worth expanding on why this is, since it also neatly illustrates why there are limits to models based on grouped counts.

When fitting a model for Poisson counts, an important step is to check the goodness of fit using the following statistic:

\[\tilde{\chi}^2 = \sum_{i=1}^n r_i^2\]

Written by: Stephen RichardsTags: Filter information matrix by tag: Pearson residuals, Filter information matrix by tag: deviance residuals, Filter information matrix by tag: Poisson distribution, Filter information matrix by tag: quantile-quantile plot

Metastatic immunity

In 2013, cancers represented more than one third of the top-fifteen causes of all-age mortality in the UK, irrespective of gender. Despite intensive efforts, for some cancers survival rates have scarcely improved for decades.
Written by: Gavin RitchieTags: Filter information matrix by tag: longevity, Filter information matrix by tag: research, Filter information matrix by tag: cancer, Filter information matrix by tag: immunotherapy